All 10 episodes of the second season will be available on Friday, June 9.
The voice cast features Nick Kroll, Maya Rudolph, Aidy Bryant, Randall Park, Keke Palmer, Brandon Kyle Goodman and David Thewlis.
Returning guest stars include Hugh Jackman, Pamela Adlon, Rosie Perez, Henry Winkler, Thandiwe Newton, Jemaine Clement, Maria Bamford, Bobby Cannavale and Cole Escola.
New guest stars include Florence Pugh, Miley Cyrus, Eugene Levy, Sam Richardson, Niecy Nash-Betts, Jason Mantzoukas and Isabella Rossellini.
Kroll co-created the Big Mouth spinoff with Andrew Goldberg, Mark Leven, Jennifer Flacket and Kelly Galuska.
